Liver Fat Scores Moderately Reflect Interventional Changes in Liver Fat Content by a Low-Fat Diet but Not by a Low-Carb Diet
نویسندگان
چکیده
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder all over the world, mainly being associated with a sedentary lifestyle, adiposity, and nutrient imbalance. The increasing prevalence of NAFLD accommodates similar developments for type 2 diabetes and diabetes-related comorbidities and complications. Therefore, early detection of NAFLD is an utmost necessity. Potentially helpful tools for the prediction of NAFLD are liver fat indices. The fatty liver index (FLI) and the NAFLD-liver fat score (NAFLD-LFS) have been recently introduced for this aim. However, both indices have been shown to correlate with liver fat status, but there is neither sufficient data on the longitudinal representation of liver fat change, nor proof of a diet-independent correlation between actual liver fat change and change of index values. While few data sets on low-fat diets have been published recently, low-carb diets have not been yet assessed in this context. AIM We aim to provide such data from a highly effective short-term intervention to reduce liver fat, comparing a low-fat and a low-carb diet in subjects with prediabetes. METHODS Anthropometric measurements, magnetic resonance (MR)-based intrahepatic lipid (IHL) content, and several serum markers for liver damage have been collected in 140 subjects, completing the diet phase in this trial. Area-under-the-responder-operator-curves (AUROC) calculations as well as cross-sectional and longitudinal Spearman correlations were used. RESULTS Both FLI and NAFLD-LFS predict liver fat with moderate accuracy at baseline (AUROC 0.775-0.786). These results are supported by correlation analyses. Changes in liver fat, achieved by the dietary intervention, correlate moderately with changes in FLI and NAFLD-LFS in the low-fat diet, but not in the low-carb diet. A correlation analysis between change of actual IHL content and change of single elements of the liver fat indices revealed diet-specific moderate to strong correlations between ΔIHL and changes of measures of obesity, ΔTG, and ΔALT (all low-fat, only) and between ΔIHL and ΔGGT (low-carb, only). With exception for a stronger decrease of triglycerides (TG) levels in the low-carb diet, there is no statistically significant difference in the effect of the diets on anthropometric or serum-based score parameters. CONCLUSION While liver fat indices have proved useful in the early detection of NAFLD and may serve as a cost-saving substitute for expensive MR measurements in the cross-sectional evaluation of liver status, their capability to represent interventional changes of liver fat content appears to be diet-specific and lacks accuracy. Liver fat reduction by low-fat diets can be monitored with moderate precision, while low-carb diets require different measuring techniques to demonstrate the same dietary effect.
منابع مشابه
Effect of Optional Consumption of Iranian Black and Green Tea on Lipid Profile of Serum and Liver in High-Fat Diet Rats
Objective: Tea, camellia sinensis, which is used as a popular beverage in Iran, may reduce the risk of cardiovascular diseases suchas coronary heart disease (CHD). In this investigation, we studied the effect of Iranian black and green tea on serum and liver lipid profile which is closely associated with obesity and many cardiovascular diseases. Materials and Methods: 24 male adult Wistar rats...
متن کاملEvaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
متن کاملEvaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice
Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...
متن کاملEffect of Hydroalcoholic Extract of Tamarix dioica on Liver Histopathological Changes in Rats Fed with High Fat Diet
Background and Objectives: Tamarix dioica is a medicinal herb in Sistan and Baluchestan, which has antidiabetic and antioxidant properties. This research aimed to investigate the effects of the hydro-alcoholic extract of this plant on liver damage caused by a high fat diet. Methods: In this experimental study, 30 males adult Wistar rats, were randomly divided into 3 equal groups. The first g...
متن کاملEvaluating the effects of metformin on irisin and serum biochemical parameters in male sprague-dawley rats fed by a high-fat emulsion diet
Irisin is a myokine secreted mostly by muscles after exercise, and its secretion level changes in metabolic disorders. The aim of present study was to investigate the effect of metformin on changes in the levels of plasma irisin, blood glucose and insulin resistance in male Sprague-Dawley rats receiving a high-fat emulsion diet. Twenty-four rats were divided into a normal control group (n = 8) ...
متن کامل